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Iron (Fe 2+ ) derived from hemoglobin metabolism and immune responses, implicated in early ALS pathogenesis via oxidative stress, contributes to motor neuron damage, exacerbating BBB permeability changes [244, 245]

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Moreover, antioxidant NAC may improve cognitive behavioral disorders in APP/PS1 mice induced by ethanol exposure by reducing oxidative stress and neuroinflammatory impairments in the brain of mouse

10.1093/jnen/60.12.1127 14 BlanchardJ